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KMID : 1098420020100040284
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Korean Journal of Medicinal Crop Science
2002 Volume.10 No. 4 p.284 ~ p.287
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Inhibitory Effects of the Extract of Rhus verniciflua Stokes on the Reverse Transcriptass of AIDS
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Kim, Myong Jo
Choi, Won Cheol/Barshinikov, A. M./Kobayashi, A.
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Abstract
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Four olefinic catechols, commonly referred to as urushiol were isolated from the sap of Korean Rhus verniciflua Stokes and had the stronger inhibitory effects on the reverse transcriptase of AIDS. The hexane extract with a inhibitory effects on reverse transcriptase was purified by silica and ODS gel column chromatography. The active compounds were identified by MS and ^1H-NMR as 3-[8´(Z), 11´(Z), 14´-pentadecatrienyl]catechol, 3-[8´(Z),11´(Z)-pentadecatrienyl]catechol, 3-[8´(Z)-penta- decenyl]catechol, and 3-pentadecatrienyl. All of these compounds showed strong inhibitory effects on reverse transcriptase of AIDS, in which 3-pentadecatrienyl exhibited the highest activity(IC_50 : 10.87 ㎍/ml)./
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KEYWORD
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